Gastrinoma (Zollinger-Ellison)

Etiology

  • Unusual neuroendocrine tumor based in pancreas

Risk Factors

  • M>f
  • Age 40-55
  • Associated w/MEN1 (rare): hyper-parathyroidism, pancreas (gastrin, VIP, insulin) and pituitary (GH, Prolactin) producing tumors

Symptoms

  • Wt loss
  • N
  • And pain related to associated ulcers
  • Heartburn/GERD sx
  • Secretory watery diarrhea→ persists w/fasing, nocturnal symptoms, cramps

Tests