Mastocytosis

Etiology

  • Mast cell infiltration of organs w/various degrees dysfxn

Symptoms

  • Episodic and along wide spectrum typically triggered by something (allergen/exposure/stress/other)
  • Flushing, angioedema, itching
  • Nasal congestion
  • Abdominal pain, diarrhea
  • Shortness of breath, chest tightness
  • Tachycardia, lightheadedness, syncope

Physical Exam Findings

  • Tachycardia
  • Up or down bp
  • Cutaneous findings inlcude hyperpigmented macules
  • Sometimes urticaria/redness induced by rubbing an affected area (Darier's sign)

Tests