- In past, linked to post-streptococcal skin or pharyngeal infxn
- Now recognized can follow other bacterial or viral infxns
- Most commonly in adults post-Staph
- Onset 10-14 d after infxn
- Painless passage of dark ("coca-cola") colored urine
- Often lab evidence decline in GFR
- Most episodes resolve spontaneously
- Can have confusion or even seizure from hypertensive encephalopathy
- Often hypertensive
- Dark colored urine
- UA + RBCs, protein; Urine microscopy w/rbc casts, dysmorphic RBCs
- Serum: decrease in GFR; low C3, CH50; if post strep, + anti-streptolysin O
- Renal bx with prolif GN, sub-epithelial immune complex deposits