Often asympotmatic x years→ picked up on incidental labs (~50% of patients)
Fever, sweats, adenopathy, fatigue, weight loss
Can transform into acute lymphoma (diffuse large B-cell or Hodgkins) called Richter's transformation→ acute fever, sweats, sudden increase in adenopathy
Can develop auto-immune hemolytic anemia or thrombocytopenia
Physical Exam Findings
Splenomegaly
Hepatomegaly
As progresses→ increased adenopathy (peripheral and central)