Chronic Lymphocytic Leukemia (CLL)

Etiology

  • Clonal proliferation of B cells

Risk Factors

  • Age > 60
  • Male sl > female
  • Agent orange exposure

Symptoms

  • Fever
  • Sweats
  • Adenopathy
  • Fatigue
  • Weight loss
  • Bleeding
  • Infections
  • Often asx x years→ picked up on incidental labs (~50% of patients)
  • Can transform into acute leukemia or lymphoma
  • Can develop auto-immune hemolytic anemia or thrombocytopenia

Physical Exam Findings

  • Splenomegaly
  • Hepatomegaly
  • As progresses→ adenopathy

Tests