Chronic Myelocytic Leukemia (CML)

Etiology

  • Associated with 9:22 chromosome translocation

Risk Factors

  • Radiation
  • Average age 55-60
  • Male sl > female

Symptoms

  • Fatigue
  • Early satiety
  • F
  • Sweats
  • Weight loss
  • Abdominal fullness
  • Chronic phase x 3-5y, then accelerated phase with blast crisis→ infection, bleeding

Physical Exam Findings

  • Often splenomegaly

Tests