Hemolytic-Uremic Syndrome (HUS - Consumptive)

Etiology

  • Thrombotic microangiopathy assoc w/hemolytic anemia, usually from exposure to shiga-toxin produced by ecoli 0157:H7
  • Consumption causes thrombocytopenia
  • Organ damage (e.g. AKI) from microvascular thrombosis

Risk Factors

  • Typically in children, though can occur in adults

Symptoms

  • Abdominal pain
  • Bloody diarrhea
  • N
  • V
  • Low urine output/anuria

Physical Exam Findings

  • Bloody stool
  • Often ill appearing
  • Petechiae and mucosal hemorrhages
  • Abdominal pain on palpation

Tests

Links