Caused by mechanical and other forces that disrupt VWF factor function
Avg age 60s, assoc w/myeloproliferative disorders, multiple myeloma or mgus, hypothyroidism, c/v dz w/high shear forces→ abnl valves, VSDs, LVADs, other
Meds→ cipro, valproate; other
Risk Factors
Meds or mechanical issues as described above
Symptoms
Later in life spontaneous mucocutanous bleeding→ gums, nosebleeds
GI bleeding from angiodysplasia (higher shear forces in these vessels unmasks the disease); Heyde's syndrome--> GI bleeding from angiodypasia associated w/Aortic Stenosis