- Loss of elasticity and sub-cutaneous fat
- Impaired nutritional status due co-morbid illness: chronic kidney disease, chronic infection, cancer, substance abuse (e.g. ETOH), other
- Sepecific nutritional deficiencies, e.g. vitamin c (see link below)
- Chronic steroid use
- Chronic underlying diseases (e.g. chronic infection, cancer, cancer treatments, chronic kidney disease, catabolic states for other reasons, etc.)
- Skin often tears rather than developing linear cut when injured→ complex wounds