Serious infections from many pathogens (bacteria, viruses, spirochetes, rickettsia, fungi, parasites) can cause systemic sx of fever, chills, and/or sweats. The site of origin of the infection (e.g. lung, kidney, etc) usually identified by presence of focal sx occurring prior to or concurrent w/generalized sx. (e.g. cough, sob, sputum→ pneumonia). Infections can also start locally and spread to other sites, leading to focal findings distant from place of origin (e.g. staph endocarditis can lead to an epidural abscess). The infections below tend to cause systemic sx w/o necessarily having localizing sx/site of origin.