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Nephrotic Syndrome
Profound loss of protein in urine→ > 3.5g protein/d; Low serum albumin, hyperlipidemia & hypercoaguability; Sometimes assoc w/decline in GFR, HTN; sometimes urine is frothy
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Nephrotic Syndrome
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Sub-Diseases
Focal Segmental Glomerulosclerosis (FSGS)
Membranous Nephropathy
Membranoproliferative Glomerulonephritis (MPGN)
Minimal Change Glomerulopathy
Diabetes
Amyloidosis
Other Systemic Diseases
Tests
Nephrotic range proteinuria: > 3.5g protein in a 24h urine collection
Spot urine protein/creat ratio: Normal < 150mg/g; 3500mg/g roughly =s 3.5g protein/24h collection
Spot urine albumin/creat ratio: Normal < 30mg/g; moderately increased albuminuria 30-300mg/g; severely increased albuminuria > 300mg/g; 3500mg/g roughly =s 3.5g albumin/24h collection